Factors associated with serum concentrations of vancomycin crystalline degradation product (CDP-1) among patients with chronic kidney disease

Table 3 Linear regression analyses of factors associated with CDP-1 trough concentration (n = 167)

Variables	Univariate				Multivariate
Variables	B	SE	t	P	B	SE	t	P	Adjusted-R²
eCrCl	−0.015	0.001	−8.772	<0.001	−0.016	0.002	−0.587	<0.001	0.537
Time interval from the initial dose to the trough level	0.051	0.011	4.486	<0.001	0.052	0.008	0.335	<0.001
vancomycin dose	0.238	0.082	2.896	<0.001	0.360	0.060	0.332	<0.001
Diabetes	−0.109	0.045	−2.426	0.016
Sepsis	−0.092	0.045	−2.033	0.043
RRT	−0.183	0.049	−3.706	<0.001
amphotericin B	−0.242	0.094	−2.555	0.011
Colistin	−0.163	0.064	−2.549	0.012
Vasopressors	−0.169	0.046	−3.649	<0.001
tCO₂	−0.024	0.010	−2.373	0.019

Adjusted for diabetes, sepsis, RRT, amphotericin B, colistin, vasopressors, tCO_2, CDP-1: Crystalline degradation product, eCrCl: Estimated creatinine clearance, RRT: Renal replacement therapy, tCO₂: Total carbon dioxide

ISSN: 1471-2369