Table 1 Baseline Characteristics of patients
Variables | Total | G1 | G2 | G3 | P |
|---|---|---|---|---|---|
(n = 167) | (n = 49) | (n = 69) | (n = 49) | ||
Age, years | 80 (70.00, 87.00) | 77 (66.50, 83.50) | 82 (72.00, 87.50) | 81 (69.50, 89.50) | 0.052 |
Sex, n (%) | |||||
Male | 111 (66.47) | 32 (65.31) | 51 (73.91) | 28 (57.14) | 0.160 |
Female | 56 (33.53) | 17 (34.69) | 18 (26.09) | 21 (42.86) | |
Body weight, kg | 62.33 ± 8.19 | 62.32 ± 8.38 | 62.89 ± 8.30 | 61.79 ± 7.90 | 0.770 |
Comorbidities, n (%) | |||||
Diabetes | 82 (49.10) | 19 (38.78) | 32 (46.38) | 31 (63.27) | 0.044 |
COPD | 68 (40.72) | 20 (40.82) | 26 (37.68) | 22 (44.90) | 0.734 |
Heart failure | 114 (68.26) | 24 (48.98) | 51 (73.91) | 39 (79.59) | 0.002 |
Hepatic dysfunction | 105 (62.87) | 32 (65.31) | 46 (66.67) | 27 (55.10) | 0.403 |
Malignant solid tumor | 39 (23.35) | 15 (30.61) | 18 (26.09) | 6 (12.24) | 0.078 |
Infectious diagnosis, n (%) | |||||
Pneumonia | 142 (85.03) | 39 (79.59) | 62 (89.86) | 41 (83.67) | 0.285 |
Catheter associated blood-stream Infection | 8 (4.79) | 2 (4.08) | 1 (1.45) | 5 (10.20) | 0.092 |
Endocarditis | 6 (3.59) | 1 (2.04) | 2 (2.90) | 3 (6.12) | 0.533 |
Intraabdominal Infection | 10 (5.98) | 5 (10.20) | 1 (1.45) | 4 (8.16) | 0.106 |
Sepsis, n (%) | 87 (52.09) | 15 (30.61) | 43 (62.32) | 29 (59.18) | 0.001 |
RRT, n (%) | 46 (27.54) | 3 (6.12) | 18 (26.09) | 25 (51.02) | <0.001 |
Vancomycin therapy | |||||
Vancomycin dose,g/d | 1.50 (1.00, 2.00) | 1.50 (1.00, 2.00) | 1.50 (1.00, 2.00) | 1.00 (1.00, 2.00) | 0.027 |
Time interval from the initial dose to trough level, days | 3.00 (2.00, 4.00) | 4.00 (3.00, 5.00) | 3.00 (2.00, 4.50) | 3.00 (2.00, 5.50) | 0.079 |
Concomitant nephrotoxic agents, n (%) | |||||
Aminoglycosides | 31 (18.56) | 5 (10.20) | 12 (17.39) | 14 (28.57) | 0.061 |
Amphotericin B | 10 (5.99) | 1 (2.04) | 4 (5.80) | 5 (10.20) | 0.233 |
Colistin | 24 (14.37) | 3 (6.12) | 13 (18.84) | 8 (16.33) | 0.137 |
Piperacillin-Tazobactam | 32 (19.16) | 12 (24.49) | 10 (14.49) | 10 (20.41) | 0.383 |
Loop diuretics | 93 (55.69) | 23 (46.94) | 46 (66.67) | 24 (48.98) | 0.056 |
NSAIDs | 41 (24.55) | 15 (30.61) | 15 (21.74) | 11 (22.45) | 0.501 |
Vasopressors | 57 (34.13) | 6 (12.24) | 28 (40.58) | 23 (46.94) | <0.001 |
Body temperature, ℃ | 37.00 (36.60, 37.80) | 36.90 (36.60, 37.65) | 37.00 (36.60, 38.00) | 37.10 (36.80, 37.95) | 0.345 |
ALB, g/L | 29.69 ± 4.09 | 29.64 ± 3.72 | 30.15 ± 4.40 | 29.16 ± 3.93 | 0.431 |
tCO2, mmol/L | 24.15 (22.10, 28.07) | 25.57 (24.55, 29.00) | 24.80 (22.35, 25.74) | 23.00 (20.95, 25.74) | <0.001 |