Table 2 Pathological features
Characteristic | Type I(n = 12) | Type II(n = 70) | Type III(n = 25) | P value | |||
|---|---|---|---|---|---|---|---|
Total(n = 70) | IgAN(n = 28) | LN(n = 27) | P value | ||||
Histological characteristics | |||||||
Number of glomeruli | 11(9,14) | 13(11,16) | 12(10,14) | 13(12,17) | 0.131 | 12(9,15) | 0.183 |
Crescents(%) | 71(57,83) | 62.5(54.5,72.9) | 63(55,69) | 66.7(54.5,75.0) | 0.523 | 66.7(51.7,75.0) | 0.153 |
Cellular crescents(%) | 17(10,49) | 26.1(11.6,50.0) | 22(13,36) | 37.5(7.7,52.4) | 0.340 | 15.8(0.0,29.7) | 0.028c |
Fibrocellular crescent(%) | 28.15 ± 15.09 | 25.07 ± 15.51 | 25.5 ± 16.1 | 25.8 ± 15.7 | 0.792 | 29.61 ± 10.60 | 0.373 |
Fibrous crescents(%) | 13(0,26) | 0.0(0.0,18.75) | 3.3(0,21.1) | 0(0,11.1) | 0.552 | 20.0(11.1,29.2) | 0.004c |
Fibrinoid necrosis, n(%) | 2(16.7) | 17(24.3) | 5(17.9) | 8(29.6) | 0.412 | 13(52) | 0.019c |
Bowman’s capsule rupture, n% | 8(66.7) | 0 | 0 | 0 | 1(4) | <0.001a, b | |
Global glomerulosclerosis(%) | 10.8(1.4,30.6) | 0(0,11.5) | 3.1(0,12.5) | 0(0,11.1) | 0.200 | 13.3(0,21.6) | 0.007c |
Interstitial inflammation, n(%) | 0.180 | 0.038a | |||||
Absent | 0(0) | 2(2.9) | 0 | 1(3.7) | 0(0) | ||
<25% | 4(33.3) | 56(80) | 22(78.6) | 20(74.1) | 18(72) | ||
25–50% | 7(58.3) | 11(15.7) | 5(17.9) | 6(22.2) | 6(24) | ||
>50% | 1(8.3) | 1(1.4) | 1(3.6) | 0 | 1(4) | ||
Interstitial fibrossis, n(%) | <0.001d | <0.001a, b,c | |||||
Absent | 1(8.3) | 19(27.1) | 2(7.1) | 9(33.3) | 0(0) | ||
<25% | 7(58.3) | 44(62.9) | 21(75) | 16(59.3) | 19(76) | ||
≥25% | 4(33.3) | 7(10) | 5(17.9) | 2(7.4) | 6(24) | ||
Immunofluorescence pattern, n(%) | |||||||
C3 Number of negative | 1(8.3) | 1(1.4) | 0 | 0 | 0.041d | 4(16.7) | <0.001a, c |
Number of 1+ | 6(50) | 16(22.9) | 6(21.4) | 4(14.8) | 11(45.8) | ||
Number ≥ 2+ | 5(41.7) | 53(75.7) | 22(78.6) | 23(85.2) | 9(37.5) | ||
IgA Number of negative | 7(58.3) | 4(5.7) | 0 | 3(11.1) | 0.004d | 19(79.2) | <0.001a, c |
Number of 1+ | 3(25) | 12(17.1) | 0 | 8(29.6) | 3(12.5) | ||
Number ≥ 2+ | 2(16.7) | 54(77.1) | 28(100) | 16(59.3) | 2(8.3) | ||
IgG Number of negative | 4(33.3) | 39(55.7) | 25(89.3) | 3(11.1) | <0.001d | 17(70.8) | 0.079 |
Number of 1+ | 5(41.7) | 21(30.0) | 3(10.7) | 17(63) | 7(29.2) | ||
Number ≥ 2+ | 3(25) | 10(14.3) | 0 | 7(25.9) | 0(0) | ||
IgM Number of negative | 8(66.7) | 15(21.4) | 5(17.9) | 2(7.4) | 0.064 | 12(50) | 0.006a, c |
Number of 1+ | 4(33.3) | 38(54.3) | 18(64.3) | 16(59.3) | 8(33.3) | ||
Number ≥ 2+ | 0(0) | 17(24.3) | 5(17.9) | 9(33.3) | 4(16.7) | ||
C1q Number of negative | 11(91.7) | 36(51.4) | 23(82.1) | 1(3.7) | <0.001d | 18(72) | <0.001a, b,c |
Number of 1+ | 1(8.3) | 15(21.4) | 5(17.9) | 7(25.9) | 7(28) | ||
Number ≥ 2+ | 0(0) | 19(27.1) | 0(0) | 19(70.4) | 0(0) | ||